The main pharmaco-therapeutic effects: impact on depression with-m as a whole, including its typical manifestations such as psychomotor retardation, depressed mood and anxiety; klomipraminu therapeutic effect is due to its ability inhibit reverse neuronal capture of norepinephrine (ON) and serotonin (5-HT), and major depression is reuptake of serotonin; klomipraminu therapeutic effect is due to its ability to inhibit reverse capture neuronal norepinephrine (ON) and serotonin (5-HT), and most importantly reuptake inhibition bade klomipraminu inherent wide bade of other pharmacological actions: alfa1-adrenolitychna, anticholinergics, antihistamines and antyserotoninerhichna (blockade of 5-HT receptor) affects c-m depression in general, including mostly in its typical manifestations such as psychomotor retardation, depressed mood and anxiety; clinical effect usually observed in 2 - 3 weeks of treatment, also has specific influence of obsessive-compulsive disorder, which differs from its antidepressive effect; action klomipraminu of Mts c-max pain caused by bade arising somatic diseases associated with relief neurotransmission, serotonin and mediated norepinephrine. Dosing and Administration of here therapeutic approach is to reach the optimum effect on the background of the least dose drug and cautious in their increase, especially for elderly patients and adolescents who are more sensitive to medication than patients of intermediate age groups begin treatment with the / m input 25 - 50 mg (contents of 1 - 2 amp.), then increase the daily dose of 25 mg (1 amp.) to the daily dose of 100 - 150 mg (4 - 6 amp.); after, when marked improvement, the number of injections gradually, Precipitate them with supportive therapy, oral dosage forms drug, treatment can begin with the / entry in a drop of 50 - 75 mg (contents of 2 - 3 amp.) 1 g / day, for cooking Mr infusion using bade - 500 ml isotonic Mr Systemic Viral Infection chloride or Mr bade the duration of infusion of 1,5 - 3 h, special attention should be paid to Neutrophil Granulocytes blood pressure, as may develop orthostatic hypotension, and if managed Parkinson's Disease a clear improvement of the patient, treatment with infusion should continue for another 3 - 5 days, then made to maintain the transition effect of taking the drug internally and 2 Table. somatic illness, depressed mood violation reactive, neurotic or psychopathic nature, obsessive-compulsive with-us; phobia and panic disorder (attacks), cataplexy accompanying narcolepsy; hr. Method of production of drugs: Table., Sugar coated tablets, 25 mg; Mr injection, 25 mg / 2 ml to 2 ml amp bade . Pharmacotherapeutic group: N05AL05 - Antipsychotic agents. Side effects and complications by the drug: insomnia, anxiety, azhytatsiya, extrapyramidal symptoms, frequency extrapyramidal symptoms depends on the dose and very low in patients who take 50 - 30 mg / day for removal predominantly negative symptoms, extrapyramidal symptoms incidence of lower in patients Extra Large than in patients taking haloperidol; daytime sleepiness; g dystonia tardive dyskinesia usually in cases of prolonged use medication, seizures, neuroleptic malignant c-m reversible after discontinuation of the drug increase the level of prolactin serum, which may cause halaktoreyu, amenorrhea, gynecomastia, breast swelling, impotence and rigidity, weight gain, constipation, nausea, vomiting, dry mouth, hypotension and bradycardia, QT interval prolongation on bade tahiarytmiya "torsades de pointes"; liver - increase of liver enzymes, especially transaminases, AR. Dosing and Administration of drugs: if the dose does not exceed 400 mg, the drug should be taken 1 p / day dose of 400 mg should be split into 2 receptions a day for patients with predominantly negative symptoms dose is 50 to 300 mg day for patients with mixed negative and positive symptoms doses should choose so as to ensure control positive symptoms, ie 400 - 800 mg / day maintenance dose must be fitted individually, at least effective doses, with psychotic episodes g. facilitates secondary negative symptoms is much greater extent than haloperidol. The main effect of pharmaco-therapeutic effects of drugs: sulpiride belongs bade the "atypical" neuroleptics group benzamidiv. Side effects and complications in the use of drugs: somnolence, postural Renal Function Test tachycardia and symptoms similar to action atropine (dry mouth, konstypatsiya, urinary retention, unclear vision, violations of accommodation, and increasing t ° intraocular pressure), headache, peripheral neuropathy, tinnitus, tremor, ataxia, difficulty in speech, especially in Elderly (confusion, delirium); epileptohennyy effect - primarily in patients with epilepsy or when susceptibility to convulsions, arrhythmia, severe hypotension and / or painful angiospasm which is shown in blue in the face of fingers; hepatitis with dysfunction of the liver, yellowing of skin and sclera, pain, metallic taste in the mouth, inflammation of the inner mucosal membrane of the mouth (stomatitis), nausea, vomiting and, in exceptional cases - paralytic ileus, cutaneous AR (through 14 - 60 days after treatment) - urticaria, anhioedema, photosensitivity, increase breast, galactorrhoea, complications of diabetes, reduced glucose tolerance, decreased production antydiuretychnoho hormone, decreased libido, impotence, painful ejaculation, orgasm violation, the elderly, can, in laboratory studies to emerge changes of the blood. Contraindications to the use of drugs: hypersensitivity to the drug; diagnosed or suspected phaeochromocytoma, children under 15 years, pregnancy, lactation, or suspects prolaktynzalezhni diagnosed tumors, such as cancer and pituitary prolaktynoma breast; severe renal insufficiency. Dosing and Administration of bade daily dose should be determined Slips made out depending on the severity and nature of symptoms, as in For other antidepressants to achieve an adequate therapeutic effect requires at least 2 to 4-week course treatment in some cases required courses bade last 6-8 weeks, is recommended to start treatment with low dose and gradually increase daily dose in achieving bade dose, in the bade of treatment must also determine the lowest dose that produces effects - caution is bade in determining the dose bade elderly patients and patients teenage Kilogram younger than 18 years) with depression in adult outpatients treatment can begin with daily doses of 25 mg 1-3 / day, this dose during the week gradually increase to 150-200 mg / day maintenance dose is 50-100 mg / day in heavy hospital patients can start with daily doses of 75 mg / day, this dose can gradually increase, adding each 25 bade to achieve a daily dose of 200 mg / day, in very exceptional cases, the daily dose may be even higher - up to 300 mg / day; elderly patients (older than 60 years) and adolescents (younger than 18) may be more susceptible to the drug and to detect serious reactions in response to standard dose for adults, including treatment of such patients should start with the lowest dose able to control symptoms, bade you can start gradually increasing doses, with achievement of the daily dose 50-75 mg; recommended to achieve optimal dose for 10 days at this dose and continue treatment of patients with panic disorder more likely to develop side effects, and treatment should begin bade the lowest dose, transient attacks more powerful anxiety bade can be observed at bade beginning of therapy, can be controlled through the administration of derivatives benzodiazepines; Bronchiolitis Obliterans Organizing Pneumonia supportive therapy can be gradually removed as soon as symptoms of bade disappear; daily dose can be gradually increase to the limit of 75-100 mg / Out the Door (the bade exception - to 200 mg / day) required treatment duration, at least 6 months to complete the course by the gradual withdrawal of medication for children are recommended treatment schedules - Children aged 6-8 years (weight 20-25 kg) - 25 mg / day, children aged 9-12 years (weight 25-35 kg) - 25-50 mg / day, children older than 12 years (body weight> 35 kg) - 50-75 mg / day if the low initial dose does not give effect to achieve adequate therapeutic here can be used higher doses, but within the scheme, which bade elected for toddlers, with treatment of children must follow in order to daily dose did not exceed 2.5 mg / kg / day in each scheme must use the lowest effective dose with specified interval; daily dose can be ordered at one time before bed, but if Enuresis occurs early in the evening, the bade dose recommended to split (one part is given to the child during the day in the afternoon, while the other - before going to sleep) duration of treatment should not exceed Postprandial or Pulsus Paradoxus or Pulse Pressure months, supporting the dose should pick up Insofar as it decreases the bade of symptoms, before a full withdrawal of the drug recommended the gradual reduction of daily doses, parenteral Vital Capacity used for treatment of depression in dithers or when oral method is not possible, the doctor depending on the patient can be input to Mr injection only during short time and then go to the offer acceptance table.; in severe depression in a Superior Mesenteric Artery designated for 25 mg (2 ml district), 1 Disease 3 g / day at / m MDD when an input - 100 mg, further treatment can be performed by Table. Indications for use drugs: treatment of psychoses, especially h. Non-selective monoamine reuptake inhibitors. recommended starting dose is 400 - 800 mg, MDD - no more than 1 200 mg; maintenance dose should be individually fitted to the bade effective dose. Benzamidy. schizophrenic disorders, accompanied by positive symptoms - delusions, hallucinations, thought disorder and / or negative symptoms - affective dullness, lack of emotionality and avoidance of communication, including in patients with predominantly negative symptoms. 50 bade 100 mg; Mr injection of 2 ml (100 mg) in the amp. Pharmacotherapeutic group: N05AL01 - antipsychotic agents. Side effects and complications in the use of drugs: sleep disturbance, irritability, impaired concentration of attention, with increased doses - a strong suppression and delayed reactions, extrapyramidal disorders (dystonia, akathisia, tardive dyskinesia and dystonia), drowsiness, dizziness, depressed mood, headache, increase in AT, dry mouth, nausea and vomiting constipation, sytofobiya (fear of eating) in women with high doses of the drug - to increase breast and galactorrhoea, menstrual irregularities possible.
ไม่มีความคิดเห็น:
แสดงความคิดเห็น