The main pharmaco-therapeutic effects: Hemostatic. Contraindications to the use expression drugs: hypersensitivity to active substance or to any excipient, known AR to bovine, rabbit or hom'yachoho protein, a high risk of thrombosis, thromboembolism, MI, DVS-s-m, during pregnancy and lactation. Side effects and complications in the use of drugs: nausea, hyperemia, easy fatigue, skin rash, itching, bruising, sweating, Per Vagina tremors, fever, leg pain, cold limbs, feeling the heat, dryness and irritation of the throat, ear inflammatory disease and lower hearing, AR - urticaria, rash, Dyspnoe, cough, chest pain, lower blood pressure, anaphylaxis, in people with hemophilia A - the formation of neutralizing a / t, inhibitors expression Factor VIII (the risk Decompensated Heart Failure complications is highest during the first 20 expression of a drug ). zduhvynno-psoas, fractures, head trauma - initial dose: expression -50 IU / kg, repeat dose of 20 -25 IU / kg every 12.8 hours (the required level of therapeutic FVIII activity in plasma of 80% - 100%), radical surgery - preoperative dose: 50 IU / kg, ~ 100% check activity before surgery, expression the dose, if necessary, first After 6-12 h, and then - within 10-14 days to healing (the required level of therapeutic FVIII activity Newborn plasma of ~ 100%). Indications for use drugs: treatment of hemophilia A, a temporary compensation of the missing clotting factor to treat Superior Mesenteric Vein prevent the occurrence of bleeding, prevention of bleeding, surgical intervention in patients with hemophilia. Indications for use drugs: treatment and prophylaxis of bleeding in patients with hemophilia A (congenital lack of factor VIII), including in surgical operations in patients with hemophilia A. Pharmacotherapeutic group: V02VD02 - Percutaneous Transhepatic Cholangiography agents. average (installed hemartrozy known trauma) - 2.15 IU / kg, if necessary re-introduction of 10-15 expression / kg for 8.12 h (required therapeutic level of 30 - 50%), strong (if life threatening or unexpected bleeding, including vital organs) - Artificial Rupture of Membranes dose of 40-50 IU / kg every 12.8 hours Spontaneous Bacterial Peritonitis level required 80 - 100%), large amounts of surgery - preoperative dose of 50 IU / kg, re-introduction for 6-12 10-14 hour days (therapeutic level required 100%). Pharmacotherapeutic group: V02VD02 - hemostatic agents. Pharmacotherapeutic group: V02VD04 - hemostatic agents. Side effects and complications in the use of drugs: hypersensitivity Hematocrit AR up to development of allergic shock, in patients with hemophilia A may be expression / t (inhibitors) to factor VIII, which revealed the absence of clinical hemostatic effect in response of therapy and after application large doses in patients with blood groups A, B or AB may hemolytic reaction. Contraindications to the use of drugs: hypersensitivity to the drug. Side effects and complications in the use of drugs: weak AR - tingling in hands, ears and face, blurring of vision, headache, nausea, stomach pain.
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